Because of its ubication, the Puerto de Guaymas has maintained the character of a regional port to national and international maritime access by the Pacific Ocean and the Sea of Cortez, with a large area of influence to the States of Sonora, Baja California Sur, Chihuahua and Sinaloa, as well as the geographical area of centro / southwest of the U.S.

The nearest cities to the Puerto de Guaymas are Hermosillo at 117km north, Ciudad Obregon at 132km southeast, and Nogales only 400km which Arizona state´s borders the state of Arizona in the U.S.